Biotin and derivatives
Medchemexpress LLC NHS-modified monomethyl auristatin F (TFA salt) | 1404073-10-4 | 96.0% | 1051.32 g/mol | C55H86N8O12 | 10 MG
NHS-Modified MMAF TFA is an NHS-activated derivative of monomethyl auristatin F provided as the trifluoroacetic acid (TFA) salt and used as a drug-linker intermediate for preparing antibody-drug conjugates (ADCs).
- NHS-activated ester for efficient conjugation to primary amines
- Provided as the TFA salt for isolation and handling
- Intended as a drug-linker intermediate for ADC synthesis
- Molecular formula C55H86N8O12; molecular weight 1051.32 g/mol
- Commonly supplied in a 10 mg pack size
Medchemexpress LLC 5-maleimido-pentanoic N-hydroxysuccinimide ester | 103750-03-4 | MFCD01318603 | 99.3% | 294.26 g/mol | C13H14N2O6 | 50 MG
Mal-C2-NHS ester (5-maleimido-pentanoic N-hydroxysuccinimide ester) is a noncleavable antibody-drug conjugate (ADC) linker that features a maleimide and an N-hydroxysuccinimide (NHS) ester for bioconjugation to thiol and amine groups during ADC synthesis.
- Noncleavable ADC linker suitable for antibody-drug conjugation.
- Maleimide group enables selective thiol coupling.
- N-hydroxysuccinimide (NHS) ester enables amine coupling.
- High purity and defined molecular weight for reproducible conjugation.
Medchemexpress LLC Biotin alkyne | 773888-45-2 | 99.53% | 281.37 | 25 MG
Biotin alkyne is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups. PROTACs themselves are compounds utilizing two different ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other a target protein, to exploit the intracellular ubiquitin-proteasome system for selective protein degradation. This product is for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC 1,2-distearoyl-sn-glycero-3-phosphoethanolamine N-hydroxysuccinimide ester | 1383932-86-2 | MFCD29267127 | 95.0% | 945.21 g/mol | C49H89N2O13P | 25 MG
DSPE-NHS is an NHS-activated phospholipid (1,2-distearoyl-sn-glycero-3-phosphoethanolamine N-hydroxysuccinimide ester) used to introduce a reactive NHS ester at liposome or nanoparticle surfaces for covalent conjugation to primary amines on proteins, peptides, and other amine-containing molecules. It self-assembles into lipid bilayers and is commonly used for antibody labeling, liposome functionalization, and nanoparticle surface modification in research applications.
- Reactive NHS ester for efficient amine coupling.
- Self-assembles into lipid bilayers for membrane incorporation.
- Enables stable amide bond formation with proteins and peptides.
- Suitable for liposome and nanoparticle surface modification.
- Available in multiple laboratory-scale package sizes for research use.
Medchemexpress LLC Butanoic acid NHS ester (BHQ-1) | 916753-61-2 | 95.4% | 601.61 g/mol | C30H31N7O7 | 10 MG
BHQ-1 NHS is an N-hydroxysuccinimide (NHS) ester derivative of a non-fluorescent quencher designed for covalent coupling to primary amines on nucleotides, oligonucleotides, and other biomolecules. It is intended for use as a quencher in fluorescence probe and assay design and for direct labeling of fluorescently labeled nucleotides. For research use only.
- Reactive NHS ester for stable amide bond formation with amines.
- Non-fluorescent quenching suitable for fluorescence-based assays.
- High purity, typically 95.44% as stated on the COA.
- Soluble in DMSO at approximately 4.35 mg/mL; ultrasonic agitation recommended.
- Provided in milligram quantities for small-scale labeling workflows.
Medchemexpress LLC Amino-PEG11-amine | 479200-82-3 | 95.0% | 50 MG
Amino-PEG11-amine is a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands. It offers an alternative strategy for creating more selective and active ER antagonists for the endocrine therapy of breast cancer. It has a molecular weight of 544.68 and a chemical formula of C24H52N2O11.
- Purity: 95.0%
- Appearance: Oil
- Color: White to off-white
- For research use only.
Medchemexpress LLC B7-H4 Human Biotin 50ug | 50ug
The B7-H4 protein acts as a negative regulator inhibiting T cell-mediated immune responses including activation proliferation cytokine production and cytotoxicity When expressed on tumor macrophages it cooperates with regulatory T cells to suppress tumor-associated antigen-specific T cell immunity B7-H4 Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived B7-H4 protein expressed by HEK293 with C-Avi C-His labeled tag
Medchemexpress LLC Biotin-azide | 908007-17-0 | 99.84% | 500 MG
Biotin-azide is a form of biotin with a terminal azide group, designed for Click Chemistry applications. It enables the preparation of various biotinylated conjugates through copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This reagent has been used in vitro for post-crosslinking chemical functionalization to isolate transcriptional protein complexes from yeast cells.
- Used in Click Chemistry to prepare biotinylated conjugates.
- Facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions.
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- Applied in post-crosslinking chemical functionalization to isolate transcriptional protein complexes.
Medchemexpress LLC Biotin-PEG7-amine | 1334172-76-7 | MFCD21363308 | 98.0% | C26H50N4O9S | 10MG
Biotin-PEG7-amine is a PEG-based biotinylation reagent containing a seven-unit polyethylene glycol spacer terminating in a primary amine. It is used as a linker in PROTAC synthesis and for bioconjugation to introduce a biotin tag for affinity capture and detection.
- PEG7 spacer improves solubility and reduces steric hindrance.
- Terminal primary amine enables coupling to activated carboxyl groups or NHS esters.
- Biotin tag allows efficient affinity capture using streptavidin or avidin systems.
- Compatible with standard peptide- and small-molecule coupling chemistries.
- High purity supports synthetic and analytical applications.
Medchemexpress LLC Bis-PEG21-NHS ester | 2221948-98-5 | 98.0% | 1 G
Bis-PEG21-NHS ester is a versatile PEG/Alkyl/ether-based linker. It serves as a PROTAC linker for the synthesis of PROTACs, which are compounds designed to recruit target proteins to E3 ubiquitin ligases for degradation. Additionally, this molecule functions as a cleavable ADC linker, essential for the construction of antibody-drug conjugates (ADCs).
- PEG/Alkyl/ether-based linker structure
- Enables synthesis of PROTACs
- Functions as a cleavable ADC linker
- For research use only
Medchemexpress LLC Biotin-PEG1-azide | 1204085-48-2 | 99.9% | 356.44 g/mol | C14H24N6O3S | 10 MG
Biotin-PEG1-azide is a biotinylated polyethylene glycol (PEG1) azide reagent used as a cleavable linker and click chemistry handle for bioconjugation and antibody-drug conjugate synthesis. It provides an azide functional group for copper-catalyzed or strain-promoted azide-alkyne cycloaddition, enabling attachment to alkyne-containing partners.
- Biotinylated PEG1 structure with terminal azide functional group.
- Suitable for CuAAC and SPAAC click chemistry reactions.
- High purity for research applications.
- Oil appearance; store frozen for stability.
- Available in small milligram pack sizes for laboratory use.
Medchemexpress LLC Bis-PEG30-NHS ester | 1633.81 | 5 MG
Bis-PEG30-NHS ester is a non-cleavable 30-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). It is designed for various laboratory applications.
- Non-cleavable 30-unit PEG ADC linker
- Used in the synthesis of antibody-drug conjugates (ADCs)
Medchemexpress LLC Biotin-PEG3-NHS ester | 1253286-56-4 | 98.4% | 100 MG
Biotin-PEG3-NHS ester is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. PROTACs typically consist of two different ligands connected by a linker; one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Serves as a linker in the construction of PROTACs
- Linker is based on Polyethylene Glycol (PEG)
- Intended for research purposes only
- Primary application is in the synthesis of PROTACs
Apexbio Technology LLC Concanavalin A (Con A)-Biotin 5x5mg(5 mg/mL)
Concanavalin A (Con A) is a lectin protein derived from Canavalia ensiformis (jack bean) with a molecular weight of approximately 104 kDa Each subunit can bind one Ca2 and one Mn2 ion and contains a carbohydrate-binding site Upon binding these metal ions Con A specifically binds to glycoproteins glycolipids and carbohydrates containing -D-glucose and -D-mannose residues Biotin is a small-molecule water-soluble vitamin that exhibits very strong affinity to avidin Concanavalin A-Biotin is a labeled protein conjugate composed of Concanavalin A linked to biotin widely used in biological research especially for detecting and quantifying biomolecules containing specific carbohydrate structures through immunohistochemistry (IHC) immunocytochemistry (ICC) and enzyme-linked immunosorbent assay (ELISA)
Medchemexpress LLC DBCO-PEG12-NHS ester | 2093934-94-0 | 96.1% | C50H71N3O18 | 25 MG
DBCO-PEG12-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide groups. PROTACs utilize the ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Features a DBCO group for SPAAC
- Facilitates strain-promoted alkyne-azide cycloaddition with azide groups
- PROTACs utilize the ubiquitin-proteasome system
- Selectively degrades target proteins